Each frame is 13mm ×17mm with one registration hole. Cartridges with 12, 20, or 24 frames are available on-line. Production variations sometimes have allowed for an additional image.

The film is fully housed in a plastic cartridge, which also registers the image when the film is advanced. There is a continuous backing paper, and the frame number is visible through a window at the rear of the cartridge. The film does not need to be rewound and is very simple to load and unload. The film is usually pre-exposed with frame lines and numbers, a feature intended to make it easier and more efficient for photofinishers to print.

Unlike later competing formats, such disc and film, processed 110 negatives are returned in strips, without the original cartridge.

The 110 cartridge was introduced by Kodak in 1972 with Kodak Pocket Instamatic cameras with Kodachrome-X, Ektachrome-X, Kodacolor II, and Verichrome Pan film. The new pocket-sized cameras became immediately popular, and soon displaced competing subminiature cameras, such as the Minolta 16 series, from the market. The 110 film width is 16mm. A four frame strip measures 111mm.

The 16mm film width allowed Kodachrome film in 110 size to be processed on the existing processing machines that processed movie films in the Standard 8 mm film and 16 mm film sizes.

Fujifilm stopped manufacturing 110 format film in September 2009. However, Lomographyre commenced 110 film production in 2011 and currently offers 110 Black and White(Orca), Colour negative(Tiger), Color slide film(Peacock), a purple-scale color negative(Lomochrome Purple) and a red-scale colour negative film(Lobster.)

Estes Industries has long marketed several model rockets, the most notable being the Astrocam, with a simple 110 camera in the nose; the shutter is triggered when the nose cone separates from the rocket body.

Tyco (in their Spy Tech line of toys) made two toy spy cameras in the early 1990s that utilized 110 film, called the Hidden Camera and Reese's Camera. The Reese's Camera natively looked like a Reese's candy box, while the Hidden Camera came with a removable cardboard cover sleeve with small cutouts for the trigger button and front lens that made it resemble a Good & Plenty candy box. The Hidden Camera had a periscope-like attachment that used a mirror for taking pictures around corners or behind objects. The Hidden Camera's shape and size is similar to that of the Minox B.

Design and technical issues

Although the format is most closely associated with cheaply produced, low-cost cameras, Canon, Minolta, Minox, Pentax, Rollei, Voigtländer, and others, as well as Kodak, offered sophisticated, expensive 110 cameras, with excellent multi-element focusing lenses and precise, electronically controlled exposure systems. Such cameras are capable of making high-quality images on 110 film. Some of these cameras are quite small and still hold appeal to subminiature-photographyenthusiasts.

The small negative size of 110 film makes it difficult to enlarge successfully. For these reasons, the 110 format is associated with prints that are often rather grainy and unsharp. This has led to the misconception that the cartridge itself is incapable of holding film flat enough for making high-quality negatives.

The 110 cartridge, as specified by Kodak, has a plastic tab on one end. Camera designers had the option of using this tab to sense film speed, enabling sophisticated cameras to switch between high and low speed film. A short tab indicated high-speed film, and a long tab indicated low-speed film. Kodak left it to the film manufacturer to decide which film speeds were high or low. Only a few cameras took advantage of this feature: Rollei A110, Canon 110 ED 20, Minolta 110 Zoom SLR Mark I/II, Minox 110S, Voigtlander Vitoret 110 EL, Pentax Auto 110 and the Kodak Ektralite 10.

Some manufacturers would vary the low speed ASA setting and then change it in later models. For example, Minox 110S low speed was 64 ASA (Kodachrome then being made for 110) and high 400 ASA: but Canon 110 ED has 80 ASA only, with the 110 ED 20 having 80 and 400 ASA.

The last 110 film that Kodak produced was ISO 400 speed packed in a cartridge that senses as "low" speed. As shown in the photograph to the right, these cartridges can be modified by hand so that they signal the proper speed to the camera.

Film types

Although the format is commonly associated with print film, Kodak also produced Kodachrome 64 slide film in 110 cartridges until 1982. In 2012 Lomographyre introduced slide film for 110 with their Peacock 200 ASA model. However, since not all 110 cameras have a settable ASA dial (low or high, depending on presence of a notch in the cassette), a neutral-density filter has to be used over the lens or the exposure compensation dial has to be used where available. Otherwise, over-exposure by a factor of x2 will result, leading to over-exposed images.

Along with standard-sized slides that fit into standard projectors, 110 slide film could also be processed into smaller format slides. The latter requires special Pocket Carousel projectors or the Leica 110 projector. The sub-miniature slides are mounted in small mounts, or for Kodachrome mounted in 35mm-sized mounts with a 110 frame. There are also mount adapters available that allow the small mounts to be projected in a common 35mm projector. These adapters were not entirely satisfactory however, as to project the smaller slide at a size comparable to that from 35mm the projector had to be moved further from the screen, resulting in a dimmer image. Dedicated 110 projectors overcame this by using a brighter lamp.

Kodak's Verichrome Pan was the only 110 black and white film produced until 2012, when Lomography manufactured their new Black and White Orca film at 100 ISO speed. This speed is supported by most 110 cameras. As of 2020, this film is still in production.